Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country.

BACKGROUND: Vitamin D plays an important role in bone mineralization, remodeling, and maintenance and therefore its deficiency may be implicated in the pathogenesis of osteoarthritis (OA). Vitamin D status was evaluated in patients with knee or hip OA scheduled for joint replacement. The impact of anthropometric parameters such as gender, age, and body mass index on vitamin D levels was also examined. The study was conducted in a Mediterranean country (Greece). MATERIALS AND METHODS: We included 164 patients with knee or hip OA scheduled for joint replacement in this study. Serum levels of 25-hydroxyvitamin D (vitamin D) were measured in routine blood samples taken from the patients at their pre-admission visit, a week before the operation, using radioimmunoassay. RESULTS: The majority of patients were vitamin D deficient (81.7 %); 15.2 % of them were vitamin D insufficient (hypovitaminosis). Only 3 % of patients were vitamin D sufficient. There was a significantly positive association between vitamin D levels and male gender. CONCLUSION: These findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece. Many other possible predisposing factors for OA should be taken into consideration. Whether treatment with vitamin D supplements may provide beneficial effects to these patients and the stage of disease in which this treatment should commence remains an issue for further scientific investigation. LEVEL OF EVIDENCE: Level IV.

The Greek version of the Hand20 questionnaire: crosscultural translation, reliability and construct validity.

The English version of Hand20 questionnaire was translated into Greek and cultural adaptation was performed. The validity was assessed in 134 patients with a variety of upper limb disorders. A comparison of Hand20 and DASH was also performed. All patients completed EQ-5D, Hand20 and DASH questionnaire. Test-retest reliability was assessed in a subgroup of 37 patients. We assessed the convergent validity of Hand20 by correlating its scores to DASH and EQ-5D scores. We also compared the completeness of Hand20 and DASH. We found no statistically significant differences in Hand20 scores between the 1st and 2nd measurements as well as a strong correlation between Hand20 and the other two questionnaires. There were also better rates of response and fewer missing data even in elderly individuals.